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25-Hydroxyvitamin D2, ≥98%

Catalog No. 878503

General Information
SynonymsErcalcidiol, 25-Hydroxyergocalciferol, 25-Hydroxycalciferol
CAS No.21343-40-8
M.F.

C28H44O2

M.W.412.65
Beilstein No.4716773
MDL No.MFCD02683431
Technical Data
AppearanceWhite to off-white solid
Purity≥98% HPLC
SolubilitySoluble to 10 mM in DMSO and to 10 mM in ethanol
Storage-20℃, under inert atmosphere, protected from light.
Description Vitamin D aids in the absorption of calcium and has central roles in bone formation and maintenance, hypertension, cancer, and immunity. Vitamin D2 is produced in fungi, including yeast, from ergosterol in response to ultraviolet radiation. 25-hydroxy Vitamin D2 is an intermediate produced from vitamin D2 by cytochrome P450 isoforms in vertebrates. It is subsequently metabolized to 1,25-dihydroxy vitamin D2, which is an agonist for the vitamin D receptor.
Biochem/physiol Actions Ergocalciferol (vitamin D2) is activated in vivo by hydroxylation to 25-hydroxyergocalciferol and 1α,25-dihydroxycalciferol. Activated Vitamin D2 molecules may be used in a wide range of studies to assess their effects on functions such as immune function and calcium homeostasis.
Safety Data
SymbolGHS08GHS06
Hazard StatementsH300 +H310 + H330-H372
Precautionary StatementsP260-P264-P280-P284-P301 + P310-P302 + P350
Hazard SymbolsT+
Risk StatementsR24/25-26-48/25
Safety StatementsS28-36/37-45
UN No.2811
Hazard Class6.1
Packing GroupII
WGK Germany3
Reference

Jones et al (1976) An in vitro study of vitamin D2 hydroxylases in the chick. J.Biol.Chem. 251 24. PMID: 1081537.

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1 mg USD96
10 mg USD480

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