Dexrazoxane, ≥99%

Catalog No. 714585

General Information

Synonyms	(+)-(S)-4,4′-Propylenedi-2,6-piperazinedione
CAS No.	24584-09-6
M.F.	C₁₁H₁₆N₄O₄
M.W.	268.27
MDL No.	MFCD00866449

Technical Data

Appearance	White or almost white crystalline powder
Melting Point (°C)	191-194℃
Specific Rotation (°)	+11° to +11.5°
Assay	≥99%
Solubility	DMSO
Storage	Room temperature
Description	Dexrazoxane is a cardioprotective compound against anthracyclines. It functions by inhibiting topoisomerase II without inducing DNA strand breaks. Dexrazoxane is a + enantiomer of razoxane.

Safety Data

Symbol	GHS07
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Hazard Symbols	Xi
Risk Statements	R36/37/38
Safety Statements	S26-36
UN No.	2811
Hazard Class	6.1
Packing Group	III
WGK Germany	3

Reference

Grauslund, M., et al. Mol. Pharmacol. 72, 1003-1014, (2007)
Agostinho, M., et al. Cancer Res. 68, 2409-2418, (2008)
Martin, E., et al. Toxicology 255, 72-79, (2009)