Mitomycin C, ≥99%

Catalog No. 410008

General Information

Synonyms	Mitocin-C, Ametycine, Mutamycin, MMC
CAS No.	50-07-7
M.F.	C₁₅H₁₈N₄O₅
M.W.	334.33
Beilstein No.	7231816
MDL No.	MFCD00078109
Derived from	Streptomyces caespitosus

Technical Data

Appearance	Deep blue purple crystalline powder
Purity	≥99% HPLC
Assay	≥970 μg/mg
Solubility	Soluble in water (0.5 mg/ml), 100% ethanol (warm) (1 mg/ml), DMSO (15 mg/ml), and methanol.
Storage	2-8℃, protected from light
Description	Mitomycin C is part of a family of azidine natural products. It is a DNA crosslinking and damaging agent making it useful as an antibiotic antitumor product. When crosslinking, Mitomycin C displays absolute specificity and high efficiency for the CpG sequence. Mammalian Cells treated with Mitomycin C (0.4 mg/mL for 5 min) can undergo apoptosis through upregulation of Bad, Fas, FasL and phosphorylated p53 along with activation of caspase-3, caspase-8, and caspase-9 activating both the intrinsic a

Safety Data

Symbol	GHS08 GHS07
Hazard Statements	H302-H351
Precautionary Statements	P281
Hazard Symbols	Xn
Risk Statements	R22-40
Safety Statements	S36/37
WGK Germany	3

Reference

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6. Seong, G.J., et al. 2005. Invest. Ophthalmol. Vis. Sci. 46: 3545-3552. PMID: 16186332