Vinblastine Sulfate, ≥98%

Catalog No. 301028

General Information

Synonyms	VLB, Vincaleukoblastine sulfate salt
CAS No.	143-67-9
M.F.	C₄₆H₅₈N₄O₉^.H₂SO₄
M.W.	909.05
Beilstein No.	3659812
EC No.	205-606-0
MDL No.	MFCD00082457
PubChem Substance ID	24278771

Technical Data

Appearance	White powder
Assay	≥98% HPLC
Solubility	Soluble to 100 mM in water
Storage	-20℃
Biological Activity	Anticancer agent; microtubule disrupter. Induces apoptosis in cultured hepatocytes and human lymphoma cells. Shown to inhibit autophagosome maturation.

Safety Data

Symbol	GHS07 GHS05
Hazard Statements	H302-H315-H318-H335
Precautionary Statements	P261-P280-P305 + P351 + P338
Hazard Symbols	Xn
Risk Statements	R22-37/38-41
Safety Statements	S26-36/39
WGK Germany	3
RTECS	YY8400000

Reference

Jordan et al (1985) Comparison of the effects of vinblastine, vincristine, vindesine, and vinepidine on microtubule dynamics and cell proliferation in vitro. Cancer Res. 45 2741. PMID: 3986806.

Tsukidate et al (1993) Microtubule antagonists activate programmed cell death (apoptosis) in cultured rat hepatocytes. Am.J.Pathol. 143 918. PMID: 8362985.

Rai and Wolf (1998) Localization of critical histidyl residues required for vinblastine-induced tubulin polymerization and for microtubulin assembly. J.Biol.Chem. 273 31131. PMID: 9813016.

Veldhoen et al (2012) The chemotherapeutic agent paclitaxel inhibits autophagy through two distinct mechanisms that regulate apoptosis. Oncogene Epub ahead of print. PMID: 22430212.