Tamoxifen, ≥99%

Catalog No. 308676

Identification

Synonyms	ICI 47699; Mammaton; Novaldex
CAS No.	10540-29-1
M.F.	C₂₆H₂₉NO
M.W.	371.51
EC No.	234-118-0
MDL No.	MFCD00010454
PubChem Substance ID	24900307

Technical Data

Appearance	White crystalline powder
Melting Point (°C)	95-98℃
Assay	≥99%
Solubility	Dichloromethane
Storage	2-8℃, protected from light
Application	Tamoxifen is a selective estrogen response modifier (SERM), protein kinase C inhibitor and anti-angiogenetic factor. Tamoxifen is a prodrug that is metabolized to active metabolites 4-hydroxytamoxifen (4-OHT) and endoxifen by cytochrome P450 isoforms CYP2D6 and CYP3A4. In breast cancer, the gene repressor activity of tamoxifen against ERBB2 is dependent upon PAX2. Blocks estradiol-stimulated VEGF production in breast tumor cells.

Safety Data

Symbol	GHS08
Hazard Statements	H350-H360-H362
Precautionary Statements	P201-P263-P308 + P313
Hazard Symbols	T
Risk Statements	R45-60-61-64
Safety Statements	S53-45
WGK Germany	3
RTECS	KR5919600

Reference

Sutherland, R., et al.: Nature, 267, 434 (1977)

Lerner, L., et al.: Cancer Res., 50, 4177 (1990)

Love, R., et al.: J. Clin. Oncol., 20 2559 (2002)

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