Vismodegib, ≥99%
Catalog No. 348722
Identification
Synonyms
GDC-0449, GDC0449
CAS No.
879085-55-9
M.F.
C
19
H
14
Cl
2
N
2
O
3
S
M.W.
421.30
MDL No.
MFCD12407408
Technical Data
Appearance
Light yellow powder
Purity
≥99% HPLC
Solubility
DMSO
Storage
-20℃
Application
Vismodegib is a potent inhibitor of Smoothened (SMO), a key mediator of Hedgehog (Hh) signaling pathway. Inhibition of SMO renders the transcription factor GLI inactive, thus preventing the expression of genes that mediate the role of Hh on tumor growth.
Safety Data
Reference
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348722, Vismodegib, ≥99%, 879085-55-9
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