Paclitaxel, ≥99%

Catalog No. 365857

Identification

Synonyms	Taxol
CAS No.	33069-62-4
M.F.	C₄₇H₅₁NO₁₄
M.W.	853.91
Beilstein No.	1420457
MDL No.	MFCD00869953
PubChem Substance ID	24900422
Derived from	Semisynthetic from Taxus baccate

Technical Data

Appearance	White powder
Specific Rotation (°)	-49° to -55°
Assay	≥99%
Solubility	Ethanol and DMSO
Storage	2-8℃
Application	Antitumor agent; promotes and stabilizes tubulin polymerization, causing cell cycle arrest. Induces autocatalytic activation of caspase-10 in CCRF-HSB-2 cells, triggering apoptosis.

Safety Data

Symbol	GHS08 GHS07 GHS05
Hazard Statements	H315-H317-H318-H334-H335-H341-H361
Precautionary Statements	P261-P280-P305 + P351 + P338-P342 + P311
Hazard Symbols	Xn
Risk Statements	R37/38-41-42/43-62-68
Safety Statements	S22-26-36/37/39-45
WGK Germany	3
RTECS	DA8340700

Reference

Merck Index 12 7117.

McGuire et al (1989) Ann.Intern.Med. 111 273. PMID: 2569287.

Rowinsky et al (1990) Natl.Cancer Inst. 82 1247. PMID: 1973737.

Rao et al (1999) J.Biol.Chem. 274 37990. PMID: 10608867.

Park et al (2004) J.Biol.Chem. 279 51057. PMID: 15452117.

Paclitaxel, ≥99%

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