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Palonosetron hydrochloride, ≥99%

Catalog No. 121607

Identification
SynonymsAloxi, Onicit, RS-25259-197
CAS No.135729-62-3
M.F.

C19H24N2O·HCl

M.W.332.87
Technical Data
AppearanceWhite to off-white powder
Specific Rotation (°)-97° to -103°
Assay≥99%
Storage2-8℃, protected from light
ApplicationPalonosetron (trade name Aloxi) is a 5-HT3 antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). Antiemetic.
Safety Data
Reference

Clark, R.D., et al.: J. Med. Chem., 36, 2645 (1993)

Wong, E.H.F., et al.: Br. J. Pharmacol., 114, 851 (1995)

Grunberg, S.M., et al.: Expert. Opin. Pharmacother., 4, 2297 (2003)

Eisenberg, P., et al.: Ann. Oncol., 15, 330 (2004)

Siddiqui, M.A.A., et al.: Drugs, 64, 1125 (2004)

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Subject 121607, Palonosetron hydrochloride, ≥99%, 135729-62-3
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