LANCRIX

Dexrazoxane, ≥99%

Catalog No. 714585

Identification
Synonyms(+)-(S)-4,4′-Propylenedi-2,6-piperazinedione
CAS No.24584-09-6
M.F.

C11H16N4O4

M.W.268.27
MDL No.MFCD00866449
Technical Data
AppearanceWhite or almost white crystalline powder
Melting Point (°C)191-194℃
Specific Rotation (°)+11° to +11.5°
Assay≥99%
SolubilityDMSO
StorageRoom temperature
ApplicationDexrazoxane is a cardioprotective compound against anthracyclines. It functions by inhibiting topoisomerase II without inducing DNA strand breaks. Dexrazoxane is a + enantiomer of razoxane.
Safety Data
SymbolGHS07
Hazard StatementsH315-H319-H335
Precautionary StatementsP261-P305 + P351 + P338
Hazard SymbolsXi
Risk StatementsR36/37/38
Safety StatementsS26-36
UN No.2811
Hazard Class6.1
Packing GroupIII
WGK Germany3
Reference

Grauslund, M., et al. Mol. Pharmacol. 72, 1003-1014, (2007)
Agostinho, M., et al. Cancer Res. 68, 2409-2418, (2008)
Martin, E., et al. Toxicology 255, 72-79, (2009)

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