Synonyms	KU 0059436, AZD 2281
CAS No.	763113-22-0
M.F.	C24H23FN4O3
M.W.	434.46

Appearance	White powder
Purity	≥98%
Solubility	DMSO, Methanol
Storage	2-8℃
Application	A potent poly(ADP-ribose) polymerase (PARP) inhibitor shown to induce significant killing of ATM-deficient lymphoid tumor cells in vitro and in vivo. Recent studies show that Olaparib increases radiosensitivity of a lung tumor xenograft, making it a potential candidate for use in combination with radiotherapy.

Weston, V.J. et al.: Blood, 116, 4578 (2010) Senra, J.M. et al.: Mol. Cancer Therap., 10, 1949 (2011) Schaefer, N.G. et al.: Nuc. Med. Comm., 32, 1046 (2011)