Medetomidine hydrochloride, ≥99%

Catalog No. 164163

Identification

CAS No.	106807-72-1
M.F.	C₁₃H1₆N_2 ^.HCl
M.W.	236.74

Technical Data

Appearance	White or off-white crystalline powder
Melting Point (°C)	151-156℃
Purity	≥99% HPLC
Solubility	Soluble to 100 mM in water
Storage	Cool & Dry
Application	Medetomidine hydrochloride is a potent and highly selective α2-AR adrenoceptor agonist (Ki values are 1.08 and 1750 nM for α2- and α1-adrenoceptors respectively). Shows greater selectivity over α1-adrenoceptors than clonidine and UK 14,304 (1620-, 220- and 300-fold respectively).
Biological Activity	Potent, highly selective α2-adrenoceptor agonist (Ki values are 1.08 and 1750 nM for α2- and α1-adrenoceptors respectively). Displays greater selectivity over α1-adrenoceptors than clonidine and UK 14,304 (1620-, 220- and 300-fold respectively). Inhibits twitch response in electrically stimulated mouse vas deferens (pD2 = 9.0). Active in vivo; displays hypotensive, bradycardic, sedative, anxiolytic, hypothermic and analgesic effects.

Safety Data

Reference

Savola et al (1986) Evidence for medetomidine as a selective and potent agonist at alpha 2-adrenoceptors. J.Aut.Pharmacol. 6 275.

Virtanen et al (1988) Characterization of the selectivity, specificity and potency of medetomidine as an α₂-adrenoceptor agonist. Eur.J.Pharmacol. 150 9. PMID: 2900154.

Scheinin et al (1989) Medetomidine - a novel α₂-adrenoceptor agonist: a review of its pharmacodynamic effects. Prog.Neuro-Psychopharm.Biol.Psychiat. 13 635.

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Medetomidine hydrochloride, ≥99%

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