Voriconazole, ≥98.5%

Catalog No. 800316

Identification

Synonyms	UK-109496
CAS No.	137234-62-9
M.F.	C₁₆H₁₄F₃N₅O
M.W.	349.31
MDL No.	MFCD00905717

Technical Data

Appearance	White to almost white crystalline powder
Melting Point (°C)	129-134℃
Specific Rotation (°)	-57.0° to -61.0°(1% in methanol)
Assay	≥98.5%
Solubility	Acetone, Methylene Chloride, DMSO
Storage	Protected from light
Application	Voriconazole is an antifungal used to treat serious fungal infections. Voriconazole inhibits ergosterol synthesis by inhibiting CYP450-dependent 14-α sterol demethylase resulting in a depletion of ergosterol in fungal cell membranes.

Safety Data

Symbol	GHS08 GHS06
Hazard Statements	H301-H351-H361-H373-H412
Precautionary Statements	P273-P281-P301 + P310
WGK Germany	3
RTECS	UV9145000

Reference

Thompson GR 3rd., et al. Expert Opin. Drug Metab. Toxicol. 6, 83-94, (2010) Scholz I., et al. Br. J. Clin. Pharmacol. 68, 906-915, (2009) Sanati, H., et al. Antimicrob. Ag. Chemother., 41, 2492 (1997)

Voriconazole, ≥98.5%

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