Prostaglandin E1, ≥99%

Catalog No. 867080

Identification

Synonyms	Alprostadil, PGE1
CAS No.	745-65-3
M.F.	C₂₀H₃₄O₅
M.W.	354.48
Beilstein No.	5294062
EC No.	212-017-2
MDL No.	MFCD00077860

Technical Data

Appearance	White to off-white crystalline powder
Purity	≥99% HPLC
Assay	95-105%
Solubility	Soluble to 50 mM in ethanol
Storage	-20℃
Application	Prostaglandin E1 (PGE1) is a major prostaglandin found in human semen that inhibits platelet aggregation. The compound has documented mouse Ki values of 1.1, 2.1, 3.6, 10 and 13 nM for the respective receptors EP3, EP4, EP1, EP2 and IP. Aside from the activity at EP receptors, PGE1 has also been shown to affect PKC, calcium movement, and adenylate cyclase yielding a multitude of physiological effects.

Safety Data

Symbol	GHS08 GHS06
Hazard Statements	H301-H361
Precautionary Statements	P281-P301 + P310
Hazard Symbols	Xn
Risk Statements	R61-22
UN No.	2811
Hazard Class	6.1
Packing Group	III
WGK Germany	3
RTECS	GY4569800

Reference

Whittle et al (1985) Specificity between the anti-aggregatory actions of prostacyclin, prostaglandin E₁ and D₂ on platelets. Adv.Exp.Med.Biol. 192 109. PMID: 2871707.

Kirtland (1988) Prostaglandin E₁: a review. Prostaglandins Leukot.Essent.Fatty Acids 32 165. PMID: 2901111.

Kiriyama et al (1997) Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells. Br.J.Pharmacol. 122 217. PMID: 9313928.

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Prostaglandin E1, ≥99%

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