FK-506 monohydrate, ≥98%

Catalog No. 534216

Identification

Synonyms	FK 506, Fujimycin, Tacrolimus
CAS No.	109581-93-3
M.F.	C₄₄H₆₉NO₁₂·H₂O
M.W.	822.03
MDL No.	MFCD11045918

Technical Data

Appearance	White or almost white crystalline powder
Assay	≥98% HPLC
Solubility	DMSO, Ethanol
Storage	-20℃
Application	Tacrolimus is a potent immunosuppressant, neuroprotective and neuroregenerative, and in vitro T cell proliferation blocker. It disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).

Safety Data

Reference

Tadano T, et al. Nihon Shokakibyo Gakkai Zasshi. 2013;110(10):1783-1789 Sierra-Paredes G, et al. CNS Neurosci Ther. 2008 Spring;14(1):36-46 Baughman G, et al. Biochem Biophys Res Commun. 1997 Mar 17;232(2):437-43 Fruman DA, et al. J Immunol. 1995 Feb 15;154(4):1846-51

FK-506 monohydrate, ≥98%

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