Brefeldin A, ≥99%

Catalog No. 517177

Identification

Synonyms	Ascotoxin, BFA, Cyanein, Decumbin
CAS No.	20350-15-6
M.F.	C₁₆H₂₄O₄
M.W.	280.36
Beilstein No.	25191
MDL No.	MFCD12913297

Technical Data

Appearance	White to off-white crystalline powder
Melting Point (°C)	199-204℃
Purity	≥99% HPLC
Solubility	DMSO, Ethanol, Methanol
Storage	-20℃
Application	Brefeldin A (BFA) is a reversible inhibitor of protein translocation from the endoplasmic reticulum (ER) to the Golgi apparatus. It blocks binding of ADP-ribosylation factor to the Golgi apparatus and inhibits GDP-GTP exchange. It can be used to induce autophagy in mammalian cells.

Safety Data

Reference

Kim S, et al. PLoS One. 2013 Dec 13;8(12):e81978 Colanzi A, et al. Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):9794-9 Vicetti Miguel RD, et al. J Immunol Methods. 2012 Oct 31;384(1-2):191-5 Schuerwegh AJ, et al Cytometry. 2001 Jun 15;46(3):172-6 Alvarez C, et al. Eur J Cell Biol. 1999 Jan;78(1):1-14

Brefeldin A, ≥99%

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