LANCRIX

Tiotropium bromide, ≥99%

Catalog No. 711578

Identification
Synonyms(1α,2β,4β,5α,7β)-7-[(2-Hydroxy-2,2-di-2-thienylacetyl)oxy]-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.02,4]nonane Bromide
CAS No.136310-93-5
M.F.

C19H22BrNO4S2

M.W.472.42
Technical Data
AppearanceWhite or almost white powder
Melting Point (°C)217-218℃
Specific Rotation (°)-0.5°~+0.5°
Assay≥99%
SolubilitySoluble in DMSO and Methanol
StorageProtected from light
ApplicationTiotropium Bromide is a muscarinic acetylcholine receptor (mAChR M) antagonist that blocks the binding of the acetylcholine ligand and subsequent opening of the ligand-gated ion channel. This stops signaling between neurons and leads to muscle relaxation.
Safety Data
Reference

Haddad, E.-B., et al.: Mol. Pharmacol., 45, 899 (1994)

Donohue, J. F., et al.: Chest, 122, 47 (2002)

Profita, M., et al.: Allergy, 60, 1361 (2005)

Dusser, D., et al.: Eur. Respir. J., 27, 547 (2006)

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Subject 711578, Tiotropium bromide, ≥99%, 136310-93-5
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