Synonyms	CPC-200; MDL-72527DA
CAS No.	93565-01-6
M.F.	C12H20N2·2HCl
M.W.	265.22
MDL No.	MFCD13152261

Appearance	Off-white crystal
Purity	≥97%
Solubility	Soluble in Water and DMSO
Storage	2-8℃
Application	MDL 72527 is an inhibitor of polyamine oxidase (spermine oxidase SMO). It blocks the production of H2O2 and increases the cells survival. Polyamine catabolism is one of the major causes of the ROS production of prostate cells in general and androgen-induced enhancement of ROS in androgen-dependent CaP cells in particular. Reports suggest that androgen stimulation of prostate cancer results in accumulation of ROS, which lead to progression of cancer, such progression is control by MDL 72527.

Symbol	GHS07
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Hazard Symbols	Xi
Risk Statements	R36/37/38
Safety Statements	S26
WGK Germany	3

Basu HS, et al. Cancer Res. 19th ed., 69, 7689-7695, (2009) Wei G, et al. Cancer Res. 7th ed., 68, 2214-2222, (2008)