Ezetimibe, ≥99%

Catalog No. 541400

Identification

Synonyms	(3R,4S)-1-(4-Fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)-2-azetidinone, sch-58235
CAS No.	163222-33-1
M.F.	C₂₄H₂₁F₂NO₃
M.W.	409.43

Technical Data

Appearance	White crystalline powder
Melting Point (°C)	164-166℃
Specific Rotation (°)	-24°~-32°
Assay	≥99% HPLC
Solubility	Soluble in DMSO and methanol
Storage	2-8℃, protected from light
Application	Ezetimibe has been reported to be a cholesterol transport inhibitor. Mechanistic studies show that this compound directly affects Niemann-Pick C1-like 1 (NPC1L1) and prevents it from incorporating into clathrin-coated vesicles. NPC1L1 is a polytopic transmembrane protein that facilitates absorption of cholesterol via clathrin/AP2-mediated endocytosis. By binding to NPC1L1, ezetimibe prevents endocytosis of this protein therefore blocking cholesterol transfer across membranes.

Safety Data

Reference

1. Mäki-Petäjä, K.M., et al. 2007. J. Am. Coll. Cardiol. 50: 852-858. PMID: 17719471 2. Ge, L., et al. 2008. Cell Metab. 7: 508-519. PMID: 18522832 3. Katsiki, N., et al. 2011. Curr Med Res Opin. 27: 693-695. PMID: 21275848 4. Ikeda, S. and Maemura, K. 2011. Curr Vasc Pharmacol. 9: 87-98. PMID: 21044017

Ezetimibe, ≥99%

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