LANCRIX

FTY720 hydrochloride, ≥99%

Catalog No. 442647

Identification
SynonymsFingolimod hydrochloride
CAS No.162359-56-0
M.F.

C19H33NO2 · HCl

M.W.343.93
Technical Data
AppearanceWhite solid
Melting Point (°C)103-106℃
Purity≥99% HPLC
SolubilityDMSO, Ethanol, Methanol
Storage2-8℃
ApplicationFTY720 is an aminopropanediol cell-permeable EDG-1 (endothelial differential gene 1 receptor) antagonist and immunosuppresive agent. It has been shown to display lymphocyte, or white blood cell, sequestration properties. When FTY720 is phosphorylated, it becomes an agonist for four sphingosine 1-phosphate receptors.
Safety Data
Reference

Brinkmann, V., et al.: Transplantation, 72, 764 (2001)

Brinkmann, et al.: J. Biol. Chem., 277, 24, 21453 (2002)

Mtaloubian, M., et al.: Nature, 427, 355 (2004)

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