LY411575, ≥98%

Catalog No. 664658

General Information

CAS No.	209984-57-6
M.F.	C₂₆H₂₃F₂N₃O₄
M.W.	479.49
MDL No.	MFCD09832551

Technical Data

Appearance	White powder
Assay	≥98%
Solubility	DMSO
Storage	-20℃
Description	LY-411575 is potent, cell permeable and selective γ-secretase inhibitor. It also inhibits Notch S3 cleavage. Studies have shown that treatment with LSN-411575 arrests KrasG12V-driven NSCLCs in association with inhibition of HES1 expression and ERK phosphorylation. It is used for Alzheimer's Disease.

Reference

Doody RS, et al. N Engl J Med. 2013 Jul 25;369(4):341-50
Sozio P, et al. J Biol Regul Homeost Agents. 2012 Apr-Jun;26(2):245-51
Busche MA, et al. Proc Natl Acad Sci U S A. 2012 May 29;109(22):8740-5
Dearmond SJ, et al. Mol Neurodegener. 2010 Jan 21;5:6
Pan X, et al. J Org Chem. 2010 Oct 1;75(19):6445-51

Size	Price	Quantity	Favorites
10 mg	USD125
50 mg	USD440

Please inquire for non-standard packs and bulk quantities.

Availability: Ships in 1-3 days

For research use only. Not for human use.

> Certificate of Analysis

> MSDS

	(*Required Field)
*Name
*Organization Name
*Country
*Email Address
Phone
Subject	664658, LY411575, ≥98%, 209984-57-6
*Message
*Code

LY411575, ≥98%

Inquire