Temozolomide, ≥99%

Catalog No. 488316

General Information

Synonyms	Methazolastone; NSC 362856; Sch 52365; Temodal; Temodar
CAS No.	85622-93-1
M.F.	C₆H₆N₆O₂
M.W.	194.15
MDL No.	MFCD00866492

Technical Data

Appearance	White or light pink powder
Assay	≥99% HPLC
Solubility	Soluble in DMSO, Acetone and Methanol
Storage	2-8℃
Description	Temozolomide is an imidazotetrazine alkylating agent. An antineoplastic.

Safety Data

Symbol	GHS08 GHS07
Hazard Statements	H302-H315-H319-H335-H350-H360
Precautionary Statements	P201-P261-P305 + P351 + P338-P308 + P313
Hazard Symbols	T
Risk Statements	R45-46-60-61-22-36/37/38
Safety Statements	S53-26-36/37-45
WGK Germany	3
RTECS	NJ5927050

Reference

Plowman et al (1994) Preclinical antitumor activity of temozolomide in mice: efficacy against human brain tumor xenografts and synergism with 1,3-bis(2-chloroethyl)-1-nitrosourea. Cancer Res. 54 3793. PMID: 8033099.

Clark et al (1995) Antitumor imidazotetraazines. 32. Synthesis of novel imidazotetrazinones and related bicyclic heterocycles to probe the mode of action of the antitumor drug temozolomide. J.Med.Chem. 38 1493. PMID: 7739008.

Bodell et al (2003) Formation of DNA adducts and induction of lacI mutations in big blue rat-2 cells treated with temozolomide: implications for the treatment of low-grade adult and pediatric tumors. Cancer Epidemiol.Biomarkers Prevent. 12 545.

Kanzawa et al (2004) Role of autophagy in temozolomide-induced cytotoxicity for malignant glioma cells. Cell Death Differ. 11 448. PMID: 14713959.