AICAR, ≥98%

Catalog No. 707041

General Information

Synonyms	Arasine; GP 1-110; NSC 105823
CAS No.	2627-69-2
M.F.	C₉H₁₄N₄O₅
M.W.	258.23
EC No.	220-097-5
MDL No.	MFCD00869751
PubChem Substance ID	24724407

Technical Data

Appearance	White crystalline powder
Purity	≥98% HPLC
Solubility	Soluble in DMSO, Methanol and Water
Storage	-20℃
Description	AICAR is a nucleoside analogue that is able to enter nucleoside pools and is able to significantly increase levels of adenosine during periods of ATP breakdown. Adenosine-regulating agents (ARAs) have been recognized for therapeutic potential in myocardial ischemia. Cardioprotective.

Safety Data

Symbol	GHS07
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Hazard Symbols	Xi
Risk Statements	R36/37/38
Safety Statements	S26-36
WGK Germany	3

Reference

Giri et al (2004) 5-Aminoimidazole-4-carboxamide-1-β-4-ribofuranoside inhibits proinflammatory response in glial cells: a possible role of AMP-activated protein kinase. J.Neurosci. 24 479. PMID: 14724246.

Ayasolla et al (2005) 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside (AICAR) attenuates the expression of LPS- and Aβ peptide-induced inflammatory mediators in astroglia. J.Neuroinflammation 2 21. PMID: 16174294.

Kanazawa et al (2007) Adiponectin and AMP kinase activator stimulate proliferation, differentiation and mineralization of osteoblastic MC3T3-EI cells. BMC Cell Biol. 8 51. PMID: 18047638.

Giri et al (2008) The role of AMPK in psychosine mediated effects on oligodendrocytes and astrocytes: Implication for Krabbe disease. J.Neurochem. 105 1820. PMID: 18248608.