Dasatinib monohydrate, ≥99%

Catalog No. 414770

General Information

CAS No.	863127-77-9
M.F.	C₂₂H₂₆ClN₇O₂S·H₂O
M.W.	506.02
MDL No.	MFCD08704581

Technical Data

Appearance	White or almost white powder
Assay	≥99% HPLC
Solubility	Slightly soluble in ethanol and methanol
Storage	Room temperature
Description	Dasatinib is a 2-aminothiazole-derived inhibitor of SRC family kinases. Dasatinib inhibits c-Abl and Bcr-Abl tyrosine kinase activity and shows efficacy against imatinib-resistant Bcr-Abl mutations.

Safety Data

Symbol	GHS08 GHS07
Hazard Statements	H302-H360-H373
Precautionary Statements	P260-P281-P301+P310-P321-P405-P501A
Hazard Symbols	T Xn
Risk Statements	R22-48/22-61
Safety Statements	S53-20-36-45-60

Reference

Doggrell, S.A. 2005. Expert Opin Investig Drugs. 14: 89-91. PMID: 15709925
Das, J., et al. 2006. J. Med. Chem. 49: 6819-6832. PMID: 17154512
Talpaz, M., et al. 2006. N. Engl. J. Med. 354: 2531-2541. PMID: 16775234