LANCRIX

LY411575, ≥98%

Catalog No. 664658

Identification
CAS No.209984-57-6
M.F.

C26H23F2N3O4

M.W.479.49
MDL No.MFCD09832551
Technical Data
AppearanceWhite powder
Assay≥98%
SolubilityDMSO
Storage-20℃
ApplicationLY-411575 is potent, cell permeable and selective γ-secretase inhibitor. It also inhibits Notch S3 cleavage. Studies have shown that treatment with LSN-411575 arrests KrasG12V-driven NSCLCs in association with inhibition of HES1 expression and ERK phosphorylation. It is used for Alzheimer's Disease.
Safety Data
Reference

Doody RS, et al. N Engl J Med. 2013 Jul 25;369(4):341-50
Sozio P, et al. J Biol Regul Homeost Agents. 2012 Apr-Jun;26(2):245-51
Busche MA, et al. Proc Natl Acad Sci U S A. 2012 May 29;109(22):8740-5
Dearmond SJ, et al. Mol Neurodegener. 2010 Jan 21;5:6
Pan X, et al. J Org Chem. 2010 Oct 1;75(19):6445-51

Availability: Ships in 1-3 days

For research use only.

Inquire

(*Required Field)
*Name
*Organization Name
*Country
*Email Address
Phone
Subject 664658, LY411575, ≥98%, 209984-57-6
*Message
*Code If it’s not clear, please click on the picture to change one.