LANCRIX

Tamoxifen, ≥99%

Catalog No. 308676

Identification
SynonymsICI 47699; Mammaton; Novaldex
CAS No.10540-29-1
M.F.

C26H29NO 

M.W.371.51
EC No.234-118-0
MDL No.MFCD00010454
PubChem Substance ID24900307
Technical Data
AppearanceWhite crystalline powder
Melting Point (°C)95-98℃
Assay≥99%
SolubilityDichloromethane
Storage2-8℃, protected from light
ApplicationTamoxifen is a selective estrogen response modifier (SERM), protein kinase C inhibitor and anti-angiogenetic factor. Tamoxifen is a prodrug that is metabolized to active metabolites 4-hydroxytamoxifen (4-OHT) and endoxifen by cytochrome P450 isoforms CYP2D6 and CYP3A4. In breast cancer, the gene repressor activity of tamoxifen against ERBB2 is dependent upon PAX2. Blocks estradiol-stimulated VEGF production in breast tumor cells.
Safety Data
SymbolGHS08
Hazard StatementsH350-H360-H362
Precautionary StatementsP201-P263-P308 + P313
Hazard SymbolsT
Risk StatementsR45-60-61-64
Safety StatementsS53-45
WGK Germany3
RTECSKR5919600
Reference

Sutherland, R., et al.: Nature, 267, 434 (1977)

Lerner, L., et al.: Cancer Res., 50, 4177 (1990)

Love, R., et al.: J. Clin. Oncol., 20 2559 (2002)

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