Zonisamide, ≥98%

Catalog No. 556740

Identification

Synonyms	AD 810, CI 912
CAS No.	68291-97-4
M.F.	C₈H₈N₂O₃S
M.W.	212.23

Technical Data

Appearance	White to light yellow crystalline powder
Assay	≥98%
Solubility	DMSO, Water
Storage	2-8℃
Application	Zonisamide is a sulfonamide antiseizure agent approved for use as an adjunctive therapy in adults with partial-onset seizures for adults. It has been shown to block voltage-sensitive T-type Ca2+ and Na+ channels, and stimulate BKCa channels. It has also been shown to modulate glutamate, monoamine, and GABA neurotransmission. It is reported to scavenge nitric oxide and hydroxyl free radicals, and inhibit lipid peroxidation. It exhibits antiParkinsonian and neuroprotective activity.

Safety Data

Reference

Huang CW, et al. J Pharmacol Exp Ther. 2007;321(1):98-106 Gluck MR, et al. J Neural Transm. 2004;111(6):713-24 Sobieszek G, et al. Pol J Pharmacol. 2003;55(5):683-9 Tokumaru J, et al. Neurochem Res. 2000;25(8):1107-11

Zonisamide, ≥98%

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