LANCRIX

Ramelteon, ≥99%

Catalog No. 255017

Identification
SynonymsRozerem, TAK-375
CAS No.196597-26-9
M.F.

C16H21NO2

M.W.259.34
Technical Data
AppearanceWhite to off-white powder
Melting Point (°C)112-116℃
Specific Rotation (°)-55° to -60°
Assay≥99% HPLC
SolubilityDMSO, Ethanol
Storage-20℃
ApplicationRamelteon is a melatonin receptor agonist with both high affinity for melatonin MT1 and MT2 receptors and selectivity over the MT3 receptor. Ramelteon demonstrates full agonist activity in vitro in cells expressing human MT1 or MT2 receptors, and high selectivity for human MT1 and MT2 receptors compared to the MT3 receptor.
Safety Data
Reference

Norris ER, et al. J Affect Disord. 2013 Jan 10;144(1-2):141-7
Liu J, et al. Int J Clin Pract. 2012 Sep;66(9):867-73
Mets MA, et al. Sleep. 2011 Oct 1;34(10):1327-34
Borja NL, et al. Clin Ther. 2006 Oct;28(10):1540-55

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